Treatment of early hypertension among persons living with HIV in Haiti: Protocol for a randomized controlled trial

Related Experiment Video

Updated: Oct 25, 2025

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

18.8K

Lily D Yan1,2,3, Vanessa Rouzier2,3, Eliezer Dade3

  • 1Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America.

Plos One
|August 5, 2021
PubMed

Insights

People living with HIV (PLWH) with prehypertension may benefit from early blood pressure treatment to reduce cardiovascular disease (CVD) risk. This trial investigates initiating antihypertensive medication sooner for PLWH with prehypertension.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Clinical Trials

Background:

  • People living with HIV (PLWH) face elevated cardiovascular disease (CVD) and mortality risks, particularly in lower-middle income countries.
  • Early intervention for prehypertension in PLWH could prevent hypertension, reduce CVD, and potentially lower mortality.
  • No prior trials have assessed early blood pressure treatment initiation for PLWH with prehypertension.

Purpose of the Study:

  • To evaluate the feasibility, benefits, and risks of initiating antihypertensive treatment in PLWH with prehypertension.
  • To compare early prehypertension treatment against the standard of care based on current WHO guidelines.
  • To assess the impact of early treatment on blood pressure changes and other health outcomes in PLWH.

Main Methods:

  • A randomized controlled trial involving 250 adults (18-65 years) living with HIV and viral suppression.
  • Participants with prehypertension (Systolic Blood Pressure [SBP] 120-139 mmHg or Diastolic Blood Pressure [DBP] 80-89 mmHg) assigned to immediate amlodipine or standard care (treatment upon hypertension diagnosis).
  • Primary outcome: Mean change in SBP at 12 months. Secondary outcomes: Feasibility, acceptability, adverse events, HIV viral suppression, medication adherence, and qualitative interviews.

Main Results:

  • The study is designed to assess the primary outcome of SBP change at 12 months.
  • Secondary outcome analysis will cover feasibility, acceptability, adverse effects, HIV viral suppression, and medication adherence.
  • Qualitative data will explore provider and participant perspectives on early amlodipine initiation and perceived CVD risk.

Conclusions:

  • PLWH exhibit higher CVD risk, suggesting a potential benefit from a lower blood pressure threshold for antihypertensive treatment initiation.
  • This trial aims to provide evidence on the efficacy and safety of early blood pressure management in this population.
  • Findings will inform clinical guidelines for managing hypertension and CVD risk in people living with HIV.
Abstract

More Related Videos

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

16.9K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

413

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
152
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
93
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
113
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
186
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
47.8K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
55