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Related Concept Videos

Accessory Structures of the Skin: Nails01:05

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Updated: Oct 25, 2025

An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
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Analysis of retrieved STRYDE nails.

Harry Hothi1, Sean Bergiers1, Johann Henckel1

  • 1The Royal National Orthopaedic Hospital, London, UK.

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|August 5, 2021
PubMed
Summary

Retrieval analysis of PRECICE STRYDE nails revealed corrosion at the extendable junctions, associated with bone changes like osteolysis. Further research is needed to understand these findings in implant surveillance.

Keywords:
Energy dispersive x-ray spectroscopyLimb lengtheningPRECICE lengthening nailPlain radiographsRetrieval analysisSTRYDE nailblood metal ionchromiumfemoral nailsinfectionosteolysisradiographstibial bonestibial nails

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Area of Science:

  • Orthopedic surgery
  • Biomaterials science
  • Medical device analysis

Background:

  • PRECICE STRYDE intramedullary nails are recently introduced devices for bone lengthening.
  • Post-market surveillance is crucial for evaluating the long-term performance and safety of orthopedic implants.

Purpose of the Study:

  • To conduct the first retrieval analysis of PRECICE STRYDE intramedullary nails.
  • To investigate the presence and characteristics of corrosion and associated bone reactions in retrieved implants.

Main Methods:

  • Ten PRECICE STRYDE nails were retrieved from six patients after successful treatment.
  • Macro- and microscopic analyses, energy dispersive X-ray spectroscopy (EDS), and metrology were performed.
  • Corrosion was graded using validated semiquantitative scoring methods.

Main Results:

  • All retrieved nails showed evidence of corrosion, primarily at screw holes and extendable junctions.
  • Five of ten nails exhibited moderate to severe junctional corrosion.
  • EDS analysis indicated chromium-rich surface deposits.
  • Radiographs revealed cortical thickening and osteolysis adjacent to the junctions in six nails.

Conclusions:

  • Corrosion at the extendable junction of PRECICE STRYDE nails is associated with adjacent cortical thickening and osteolysis in united bone.
  • Further investigation with larger sample sizes is necessary to fully elucidate the relationship between corrosion and bony changes.
  • Understanding surgeon, implant, and patient factors influencing these outcomes is essential.