Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

7.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
7.0K
Glaucoma: Overview01:25

Glaucoma: Overview

1000
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1000
Visual Agnosia01:12

Visual Agnosia

482
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
482

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration: a MACUSTAR study report.

Scientific reports·2022
Same author

Deep Learning to Predict Geographic Atrophy Area and Growth Rate from Multimodal Imaging.

Ophthalmology. Retina·2022
Same author

Spectrally resolved autofluorescence imaging in posterior uveitis.

Scientific reports·2022
Same author

[Erratum to: First clinical results with the PAUL® Glaucoma Implant at the University Eye Hospital Bonn].

Die Ophthalmologie·2022
Same author

A CONSENSUS ON RISK MITIGATION FOR BROLUCIZUMAB IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Patient Selection, Evaluation, and Treatment.

Retina (Philadelphia, Pa.)·2022
Same author

Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes.

Translational vision science & technology·2022

Related Experiment Video

Updated: Oct 25, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.8K

Visual Dysfunction and Structural Correlates in Sorsby Fundus Dystrophy.

Kristin Raming1, Martin Gliem2, Peter Charbel Issa3

  • 1From the Department of Ophthalmology (K.R., J.B., P.H., F.G.H., M.P., K.H.), University of Bonn, Bonn, Germany; Center for Rare Diseases (K.R., P.H., F.G.H., K.H.), University of Bonn, Bonn, Germany.

American Journal of Ophthalmology
|August 5, 2021
PubMed
Summary
This summary is machine-generated.

Sorsby fundus dystrophy (SFD) impairs night vision (scotopic function) even without visible eye changes. Early detection is possible with specific visual function tests, and vitamin A may improve vision.

Keywords:
Bruch's membraneDark adaptationFundus-controlled perimetryMicroperimetryOutcome measuresSorsby Fundus Dystrophy

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.9K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.2K

Related Experiment Videos

Last Updated: Oct 25, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

3.8K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.9K
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
07:08

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Published on: January 10, 2019

10.2K

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Visual Neuroscience

Background:

  • Sorsby fundus dystrophy (SFD) is a rare inherited retinal disease.
  • Understanding the early functional deficits is crucial for developing effective interventions.

Purpose of the Study:

  • To identify morphological factors causing rod and cone dysfunction in SFD.
  • To compare visual function tests for their utility in interventional trials for SFD.

Main Methods:

  • Prospective cross-sectional study involving 16 SFD patients and 20 controls.
  • Comprehensive visual function testing including visual acuity, contrast sensitivity, and dark-adapted perimetry.
  • Multimodal imaging and machine learning for structure-function correlation analysis.
  • Longitudinal assessment of one patient following high-dose vitamin A supplementation.

Main Results:

  • SFD patients showed impaired low luminance visual acuity (LLVA) and significantly delayed dark adaptation (DA) compared to controls.
  • Scotopic visual function tests revealed significant rod dysfunction, even without apparent funduscopic changes.
  • Machine learning accurately predicted visual sensitivity based on structure-function correlations.
  • One patient demonstrated marked improvement in rod-mediated dark adaptation (RMDA) and DA thresholds after vitamin A supplementation.

Conclusions:

  • SFD causes severe scotopic visual dysfunction, detectable early via specialized tests, independent of funduscopic alterations.
  • Scotopic visual function tests are more sensitive than best-corrected visual acuity (BCVA) for early SFD detection.
  • Observed improvement after vitamin A suggests a potential therapeutic role, possibly addressing local vitamin A deficiency due to Bruch's membrane defects.