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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
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The Term Newborn: Early-Onset Sepsis.

Karen M Puopolo1, Sagori Mukhopadhay1, Adam Frymoyer2

  • 1Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia Newborn Care at Pennsylvania Hospital, 800 Spruce Street, Philadelphia, PA 19107, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Clinics in Perinatology
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Early-onset neonatal sepsis in term infants is rare, prompting new management strategies. Reducing diagnostic tests and empirical treatment is crucial for at-risk newborns.

Keywords:
AntibioticsEarly-onset sepsisNewbornRisk assessment

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Area of Science:

  • Neonatal Medicine
  • Infectious Disease Epidemiology

Background:

  • Neonatal sepsis, particularly early-onset, presents evolving epidemiological patterns in term infants.
  • The declining incidence necessitates a re-evaluation of current management protocols for at-risk newborns.

Purpose of the Study:

  • To address the changing epidemiology of early-onset neonatal sepsis.
  • To propose refined strategies for managing newborns potentially exposed to sepsis.

Main Methods:

  • Review of current epidemiological data on neonatal sepsis.
  • Analysis of diagnostic testing and empirical treatment approaches.
  • Development of evidence-based recommendations for risk stratification and management.

Main Results:

  • Early-onset neonatal sepsis is increasingly rare among term infants.
  • New strategies focus on reducing unnecessary diagnostic evaluations and empirical antibiotic use.
  • Refined approaches aim to optimize care while minimizing overtreatment.

Conclusions:

  • Healthcare facilities must prioritize the adoption and refinement of updated management strategies.
  • Revised protocols are essential for the effective and safe care of newborns at risk for sepsis.
  • Adapting to the changing epidemiology improves patient outcomes and resource allocation.