Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.0K
Abnormal Proliferation02:23

Abnormal Proliferation

4.8K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and influence in the spread of collective violence.

Social science research·2025
Same author

Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue.

Nature biomedical engineering·2021
Same author

Loss of renal function and microvascular blood flow after suprarenal aortic clamping and reperfusion (SPACR) above the superior mesenteric artery is greatly augmented compared with SPACR above the renal arteries.

Journal of vascular surgery·2007
Same author

Preliminary results of subintimal angioplasty for limb salvage in lower extremities with severe chronic ischemia and limb-threatening ischemia.

Journal of vascular surgery·2006
Same author

Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation.

Journal of pharmaceutical sciences·2006

Related Experiment Video

Updated: Oct 25, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.1K

Aggressive Nodular Malignant Melanoma.

Daniel J Myers1,2, Ethan A Hyde3

  • 1Dermatology, Northwestern University Feinberg School of Medicine, Chicago, USA.

Cureus
|August 6, 2021
PubMed
Summary

Nodular melanoma, a severe skin cancer subtype, can lead to poor prognoses due to invasion and metastasis. This case highlights a large primary melanoma causing breathing difficulties and explores patient care delays.

Keywords:
breslow's depthclark levelmalignantmelanomanodular

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.6K

Related Experiment Videos

Last Updated: Oct 25, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.1K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.2K
A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.6K

Area of Science:

  • Oncology
  • Dermatology

Background:

  • Nodular melanoma is an aggressive subtype of malignant melanoma.
  • It is characterized by local invasion and a high propensity for distant metastasis.
  • These factors contribute to a generally poor prognosis.

Observation:

  • A rare case of a significantly large primary nodular melanoma is presented.
  • The tumor caused progressive dyspnea, indicating substantial impact on vital functions.
  • This observation underscores the potential for extensive tumor burden in nodular melanoma.

Findings:

  • The case details the clinical presentation and diagnostic challenges of a massive primary melanoma.
  • Management strategies employed for this extensive tumor are discussed.
  • Factors contributing to delayed medical care seeking by patients are elucidated.

Implications:

  • Early detection and prompt treatment are crucial for improving outcomes in nodular melanoma.
  • Understanding patient delays in seeking care is vital for public health interventions.
  • This case contributes to the literature on rare, large primary melanomas and their management.