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Serum thyroid-stimulating hormone receptor antibody levels and thyroid dysfunction after hysterosalpingography: a
Shuhei So1,2, Koshi Hashimoto3, Masatomo Mori4
1Department of Reproductive and Perinatal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Summary
Thyroid-stimulating hormone receptor antibody (TRAb) levels are linked to thyrotoxicosis after hysterosalpingography (HSG). Intermediate TRAb levels significantly increase the risk of developing thyrotoxicosis following HSG procedures.
Area of Science:
- Endocrinology
- Radiology
Background:
- Hysterosalpingography (HSG) utilizes iodine contrast media, which can precipitate thyroid dysfunction, including thyrotoxicosis and hypothyroidism.
- Thyroid-stimulating hormone receptor antibody (TRAb) is a key indicator for Graves' disease, an autoimmune thyroid condition.
Purpose of the Study:
- To investigate the association between serum TRAb levels and abnormal thyroid function post-HSG.
- To determine if pre-existing TRAb levels predict the risk of thyrotoxicosis after HSG.
Main Methods:
- Serum TRAb levels were screened in 362 patients undergoing initial consultation at Tawara IVF Clinic.
- The correlation between TRAb levels and thyroid function changes after HSG was analyzed.
Main Results:
- Two out of 98 women (2.04%) who underwent HSG developed overt thyrotoxicosis.
- A significantly higher incidence of thyrotoxicosis was observed in women with intermediate TRAb levels (28.6%) compared to those with low TRAb levels (0.0%).
Conclusions:
- Elevated serum TRAb levels are significantly associated with an increased risk of developing thyrotoxicosis after HSG.
- TRAb screening may help identify patients at higher risk for thyroid dysfunction following HSG.
