Therapeutic gas delivery strategies

Area of Science:

• Biomedical Engineering
• Drug Delivery Systems
• Nanomedicine

Background:

• Emerging pharmaceutical applications of gas molecules offer novel therapeutic solutions.
• Beyond traditional medical gases (O2, NO), gases like H2, H2S, SO2, and CO show promise in disease management.
• Clinical application of gas therapy is advancing, highlighting its therapeutic potential.

Purpose of the Study:

• To review and analyze various strategies for delivering therapeutic gases.
• To discuss the challenges and advancements in gas molecule delivery for effective gas therapy.
• To explore future directions in intelligent gas delivery and catalyst use for gas therapy.

Main Methods:

• Summarizing direct gas molecule delivery via chemical and physical absorption.
• Reviewing inorganic, organic, and hybrid gas prodrugs for controlled release.
• Analyzing natural, artificial, and hybrid catalysts for therapeutic gas generation.

Main Results:

• Various gas delivery strategies, including prodrugs and catalysts, have been developed to enhance efficiency and control.
• Each method presents distinct advantages and limitations that impact clinical feasibility.
• The development of advanced delivery systems is key to overcoming challenges associated with gas molecule transport.

Conclusions:

• Effective delivery of therapeutic gases is paramount for successful gas therapy.
• Intelligent delivery systems and novel catalysts are critical for future advancements in the field.
• Gas therapy holds significant potential for treating various diseases, particularly in areas like oncologic disease nanomedicine.