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Related Experiment Video

Updated: Oct 25, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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[Hepatits E virus can cause neurological disorders].

Thomas Møhl1, Christian Peter Midtgaard Stenør

  • 1Thomasmohl@hotmail.com.

Ugeskrift for Laeger
|August 6, 2021
PubMed
Summary

Hepatitis E virus (HEV) causes acute hepatitis globally and neurological issues like neuralgic amyotrophy. Consider HEV in patients with neurological symptoms and elevated liver enzymes, as research on HEV-related nerve injury is ongoing.

Area of Science:

  • Hepatology
  • Neurology
  • Infectious Diseases

Background:

  • Hepatitis E virus (HEV) is a prevalent cause of acute hepatitis worldwide.
  • HEV is endemic in Europe, including Denmark, with increasing recognition of its non-liver manifestations.
  • Neurological complications are significant non-liver manifestations of HEV infection.

Purpose of the Study:

  • To review the neurological manifestations associated with Hepatitis E virus infection.
  • To highlight the importance of considering HEV in patients presenting with specific neurological conditions.
  • To identify gaps in current research regarding HEV-related neurological injury.

Main Methods:

  • Literature review of studies on HEV and neurological manifestations.
  • Summary of reported cases and clinical presentations.

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  • Synthesis of evidence linking HEV to neurological syndromes.

    • Main Results:

    • Neurological conditions, including neuralgic amyotrophy and Guillain-Barré syndrome, are key non-liver manifestations of HEV.
    • Unexplained mild to moderate elevations in liver enzymes alongside neurological symptoms warrant consideration of HEV.
    • HEV infection should be considered in the differential diagnosis for certain neurological presentations.

    Conclusions:

    • HEV infection can present with significant neurological complications.
    • Clinical suspicion of HEV is crucial in patients with neurological symptoms and abnormal liver function tests.
    • Further research is essential to fully understand and address HEV-related neurological injury.