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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Cells of the Epidermis01:24

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Related Experiment Video

Updated: Oct 25, 2025

Merkel Cell Polyomavirus Infection and Detection
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Merkel Cell Polyomavirus Infection and Detection

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[Merkel cell carcinoma].

Simon Naseri1, Torben Steiniche, Morten Ladekarl

  • 1Leehmaan@hotmail.com.

Ugeskrift for Laeger
|August 6, 2021
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma, a rare neuroendocrine skin cancer, is linked to Merkel cell virus and UV radiation. This review summarizes diagnosis and treatment options for this condition.

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Area of Science:

  • Oncology
  • Dermatology
  • Virology

Background:

  • Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer.
  • Etiology involves Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation exposure.
  • MCC commonly presents on sun-exposed skin areas.

Purpose of the Study:

  • To provide a comprehensive review of Merkel cell carcinoma.
  • To summarize current diagnostic and treatment modalities for MCC.
  • To highlight the epidemiology and risk factors associated with MCC.

Main Methods:

  • Literature review of Merkel cell carcinoma diagnosis and treatment.
  • Summary of epidemiological data for Danish patients.
  • Overview of therapeutic approaches including surgery, radiation, and systemic therapies.

Main Results:

  • Approximately 25 Danish patients are diagnosed with MCC annually.
  • Definitive diagnosis relies on histopathological examination by a pathologist.
  • Treatment strategies encompass surgery, radiotherapy, immunotherapy, and chemotherapy.

Conclusions:

  • Merkel cell carcinoma requires a multidisciplinary approach for optimal management.
  • Early diagnosis and prompt treatment are crucial for patient outcomes.
  • Ongoing research is vital for advancing MCC treatment strategies.