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Utility of Transcranial Magnetic Simulation in Studying Upper Motor Neuron Dysfunction in Amyotrophic Lateral
Nimeshan Geevasinga1, Mehdi Van den Bos1, Parvathi Menon1
1Western Clinical School, University of Sydney, Sydney, NSW 2006, Australia.
Brain Sciences
|August 6, 2021
Summary
Transcranial magnetic stimulation (TMS) offers insights into motor cortex function and excitability in amyotrophic lateral sclerosis (ALS). This review explores TMS utility in diagnosing ALS, understanding its pathogenesis, and examining genetic forms.
Area of Science:
- Neuroscience
- Neurology
- Neurophysiology
Background:
- Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron dysfunction with diverse clinical presentations and phenotypes.
- Genetic factors and the link between ALS and frontotemporal dementia highlight the significance of cortical dysfunction.
Purpose of the Study:
- To review the diagnostic and pathogenic utility of transcranial magnetic stimulation (TMS) in amyotrophic lateral sclerosis (ALS).
- To explore insights into cortical excitability in ALS, including genetic and variant forms, using TMS.
Main Methods:
- Review of existing literature on transcranial magnetic stimulation (TMS) applications in amyotrophic lateral sclerosis (ALS).
- Analysis of TMS data concerning motor cortex function and excitability in various ALS phenotypes.
Main Results:
- Transcranial magnetic stimulation (TMS) is a valuable noninvasive tool for assessing motor cortex excitability in ALS.
- TMS provides insights into the diagnosis and pathogenesis of ALS, including genetic and variant forms.
Conclusions:
- Transcranial magnetic stimulation (TMS) enhances the understanding of cortical dysfunction in amyotrophic lateral sclerosis (ALS).
- Further exploration of TMS in ALS diagnosis, pathogenesis, and genetic subtypes is warranted.
