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Published on: January 30, 2017
Positive Rate of Tests for Group a Streptococcus and Viral Features in Children with Acute Pharyngitis
1Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si 18450, Gyeonggi-do, Korea.
Insights
Group A Streptococcus (GAS) pharyngitis is less common in children under 3. Testing for GAS in young children with viral symptoms is often unnecessary, highlighting the need for judicious antibiotic use.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Group A Streptococcus (GAS) is a significant cause of acute pharyngitis in children.
- Accurate diagnosis of GAS pharyngitis is crucial for appropriate treatment and preventing complications.
Purpose of the Study:
- To investigate the positive rate of GAS tests and the prevalence of clinical viral features in children diagnosed with acute pharyngitis.
- To assess the GAS positive rate in relation to age and the presence of viral symptoms.
Main Methods:
- Retrospective review of patients under 15 years old with both rapid antigen detection test (RADT) and throat culture results for GAS.
- Exclusion of patients with influenza or recent antibiotic use.
- Analysis of GAS positive rates based on age groups and presence of viral features.
Main Results:
- The overall GAS positive rate was 11.4%.
- GAS positive rates were significantly lower in children under 3 years old (1.8%) compared to older children (19.4%).
- The GAS positive rate did not differ significantly between patients with and without viral features.
Conclusions:
- GAS pharyngitis is less prevalent in very young children (<3 years old).
- Testing for GAS is frequently performed in young children, often without a clear indication.
- Judicious use of laboratory testing and antibiotic prescriptions for GAS pharyngitis is recommended.
Abstract:
Group A streptococcus (GAS) is an important cause of acute pharyngitis. We investigated the positive rate of GAS tests and clinical viral features in children with acute pharyngitis. A retrospective review was conducted for patients <15 years old with both rapid antigen detection test (RADT) and throat culture results. Patients were excluded if they were diagnosed with influenza or had received antibiotics within two weeks before these tests. A total of 377 patients were eligible. The median age of patients was 3.5 years, and 45.4% of total patients were <3 years old. Among all patients, 68.7% had at least one viral feature, and 39% had more than two. The overall positiv rate for GAS was 11.4%. The GAS positive rate was significantly lower in patients <3 years old than in older patients (1.8% vs. 19.4%, p < 0.0001). The overall sensitivity and specificity of RADT were 75.0% (95% CI: 57.8-87.9) and 97.9% (95% CI: 95.8-99.2), respectively. The GAS positive rate was not significantly different between patients with and without viral features (12.4% vs. 9.3%, p = 0.4854). In patients aged 3-14 years, the GAS positive rate was not associated with the modified Centor score or the frequency of clinical viral features. Despite a low prevalence of GAS pharyngitis, testing for GAS was frequently performed in children <3 years old in this study. Appropriate use of laboratory testing for GAS pharyngitis and judicious prescription of antibiotics were imperative.
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