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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
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Immunometabolism Modulation in Therapy.
Ezequiel Monferrer1,2, Sabina Sanegre1,2, Isaac Vieco-Martí1,2
1Department of Pathology, Medical School, University of Valencia-INCLIVA Biomedical Health Research Institute, 46010 Valencia, Spain.
Biomedicines
|August 6, 2021
Summary
Cancer metabolism research reveals how oncometabolites and immunometabolites influence immune cells. Understanding these metabolic pathways offers new immunotherapy strategies by targeting key metabolites.
Area of Science:
- Oncology
- Immunology
- Metabolic pathways
Background:
- Cancer biology requires a holistic view of the tumor ecosystem, including cellular metabolism and immune interactions.
- Understanding molecular alterations in tumor development is crucial for novel therapeutic strategies.
- Metabolic regulation presents a promising avenue for enhancing cancer immunotherapy.
Purpose of the Study:
- To review the role of oncometabolites and immunometabolites in modulating immune cell function within the tumor microenvironment.
- To explore the plasticity of the immune response and its impact on immunotherapy effectiveness.
- To highlight therapeutic opportunities in controlling metabolite balance for cancer treatment.
Main Methods:
- Literature review of cancer metabolism and immunometabolism.
- Analysis of the impact of metabolites, including TCA intermediates, on immune cells (MDSCs, T lymphocytes, TAMs, DCs).
- Discussion of immune response plasticity and its implications for immunotherapy.
Main Results:
- Oncometabolites and immunometabolites significantly influence the pro/anti-inflammatory activity of various immune cells.
- Metabolic reprogramming of immune cells is a key factor in the tumor microenvironment.
- Immune response plasticity affects immunotherapy outcomes.
Conclusions:
- Targeting cancer cell and immune cell metabolism can optimize immunotherapy.
- Metabolite-based interventions offer a novel approach to cancer treatment.
- A comprehensive understanding of tumor ecosystem metabolism is essential for advancing cancer therapy.
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