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Robot-Assisted Gait Training in Patients with Multiple Sclerosis: A Randomized Controlled Crossover Trial.

Cristiano Sconza1,2, Francesco Negrini3, Berardo Di Matteo2,4

  • 1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Italy.

Medicina (Kaunas, Lithuania)
|August 6, 2021
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Summary

Robot-assisted gait training (RAGT) combined with physiotherapy significantly improves walking ability and motor function in multiple sclerosis (MS) patients compared to conventional training alone.

Keywords:
exercisegait recoverymultiple sclerosisrehabilitationrobotic training

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Biomedical Engineering

Background:

  • Gait disorders are a major cause of disability and reduced quality of life in multiple sclerosis (MS).
  • Improving walking ability is a key objective in MS rehabilitation.
  • Conventional gait training may not fully address the complexities of MS-related gait impairments.

Purpose of the Study:

  • To evaluate the effectiveness of robot-assisted gait training (RAGT) combined with physiotherapy for MS patients.
  • To compare RAGT plus physiotherapy against conventional gait training alone.
  • To assess improvements in gait parameters, motor function, and daily living activities.

Main Methods:

  • A randomized controlled crossover trial involving 27 MS patients (EDSS 3.5-7), with 17 completing the study.
  • Participants underwent five weeks of conventional gait training, with or without RAGT.
  • Evaluations included the 25-foot walk test (25FW), 6-minute walk test (6MWT), and various motor and functional assessments.

Main Results:

  • Both RAGT and conventional training improved gait parameters and motor abilities.
  • The RAGT group showed significantly greater improvements in the 25FW (p=0.004) and 6MWT (p=0.022) compared to the control group.
  • Robot-assisted gait training demonstrated superior effectiveness in enhancing gait speed and endurance.

Conclusions:

  • Robot-assisted gait training is a viable therapeutic option for managing gait disorders in multiple sclerosis.
  • Combining RAGT with physiotherapy offers enhanced benefits over conventional gait training for MS patients.
  • RAGT shows particular promise in improving gait speed and resistance in individuals with MS.