Related Experiment Video

Updated: Oct 25, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K

Relationship between Vascular Calcification, Protein-Energy Wasting Syndrome, and Sarcopenia in Maintenance Automated

Gustavo Leal-Alegre1, Claudia Lerma2, Gabriela Leal-Escobar1

  • 1Department of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico 04480, Mexico.

Life (Basel, Switzerland)
|August 6, 2021
PubMed

Insights

Vascular calcification, sarcopenia, and protein-energy wasting syndrome (PEW) are linked in automated peritoneal dialysis patients, primarily driven by age. Nutritional status is key for preventing vascular calcification.

Area of Science:

  • Nephrology
  • Gerontology
  • Cardiology

Background:

  • Vascular calcification is prevalent in chronic kidney disease (CKD) patients, predicting cardiovascular mortality.
  • Sarcopenia and protein-energy wasting syndrome (PEW) are also linked to increased mortality in CKD.
  • Automated peritoneal dialysis (APD) patients face significant risks from these conditions.

Purpose of the Study:

  • To investigate the relationship between vascular calcification, sarcopenia, and PEW in APD patients.
  • To identify factors associated with vascular calcification in this population.

Main Methods:

  • Study included 51 maintenance APD patients (mean age 39 ± 14 years).
  • Vascular calcification assessed via radiographs (abdomen, pelvis, hands).
  • Sarcopenia evaluated using bioimpedance analysis and hand grip strength.
  • Malnutrition-Inflammation Score and PEW presence were also assessed.

Main Results:

  • Vascular calcification was observed in 41.2% of patients.
  • Univariate analysis linked vascular calcification to age, Malnutrition-Inflammation Score, PEW, sarcopenia, and diabetes.
  • Multivariate analysis revealed age as the sole independent predictor of vascular calcification.

Conclusions:

  • A significant association exists between vascular calcification, PEW, and sarcopenia in APD patients.
  • These associations are age-dependent, highlighting the critical role of nutritional status.
  • Maintaining good nutritional status is crucial for preventing vascular calcification in APD patients.

Keywords:
dialysisend-stage renal failuremalnutritionsarcopeniavascular calcification

More Related Videos

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

11.0K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.8K

Related Concept Videos

Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
238
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
153
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
159
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
204
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
2.4K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.1K