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Updated: Oct 25, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Hippo Signaling Pathway as a New Potential Target in Non-Melanoma Skin Cancers: A Narrative Review

Igor Aleksander Bednarski1, Magdalena Ciążyńska2, Karolina Wódz3

  • 1Department of Dermatology, Pediatric Dermatology and Dermatological Oncology, Medical University of Lodz, 91-347 Lodz, Poland.

Life (Basel, Switzerland)
|August 6, 2021
PubMed

Insights

The Hippo pathway, involved in tissue growth, may drive non-melanoma skin cancers (NMSCs). Further research could reveal it as a therapeutic target for skin cancer treatment.

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), are the most common human cancers.
  • The precise mechanisms driving NMSC development remain incompletely understood.
  • The Hippo signaling pathway, a regulator of tissue homeostasis, has emerged as a potential player in carcinogenesis.

Purpose of the Study:

  • To review the current evidence linking the Hippo pathway and its effector, YAP, to skin carcinogenesis.
  • To explore the potential of the Hippo pathway as a therapeutic target for NMSCs.

Main Methods:

  • Literature review of studies investigating the Hippo pathway in skin cancer.
  • Analysis of the role of YAP in cell proliferation, tissue growth, and tumor development.

Main Results:

  • The Hippo pathway regulates tissue growth and YAP is implicated in numerous cancers.
  • Upregulation and overexpression of YAP are observed in various tumors.
  • Disrupted YAP/Hippo signaling is associated with cancer progression, invasion, and metastasis.

Conclusions:

  • The Hippo pathway is a significant regulator of skin carcinogenesis.
  • Targeting the YAP/Hippo signaling pathway presents a promising avenue for future NMSC therapies.
Keywords:
Hippo signalingYAPbasal cell carcinomasquamous cell carcinoma

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