Determinants of Longitudinal Change of Glycated Hemoglobin in a Large Non-Diabetic Population

Although many cross-section studies have assessed the determinants of glycated hemoglobin (HbA_1c), there have been limited studies designed to evaluate the temporal correlates of HbA_1c in non-diabetic patients. This study aimed to identify the major determinants of longitudinal change of HbA_1c in non-diabetic patients. This study included subjects from the 104,451 participants enrolled between 2012 and 2018 in the Taiwan Biobank. We only included participants with complete data at baseline and follow-up (n = 27,209). Patients with diabetes at baseline or follow-up (n = 3983) were excluded. Finally, 23,226 participants without diabetes at baseline and follow-up were selected in this study. △Parameters was defined as the difference between the measurement baseline and follow-up. Multivariable linear regression analysis was used to identify the major determinants of HbA_1c longitudinal change (△HbA_1c). During a mean 3.8 year follow-up, after multivariable analysis, new-onset hypertension (coefficient β: 0.014, p < 0.001), high △heart rate (coefficient β: 0.020, p = 0.002), high △BMI (coefficient β: 0.171, p = 0.028), high △fasting glucose (coefficient β: 0.107, p < 0.001), low △creatinine (coefficient β: -0.042, p < 0.001), high △total cholesterol (coefficient β: 0.040, p < 0.001), high △hemoglobin (coefficient β: 0.062, p < 0.001), high △GPT (coefficient β: 0.041, p = 0.001), and low △albumin (coefficient β: -0.070, p < 0.001) were significantly associated with high △HbA_1c. In non-diabetic population, strategies to decrease the development of new-onset hypertension, resting heart rate, body mass index, fasting glucose, total cholesterol, and GPT and increase serum albumin level might be helpful in slowing the longitudinal change of HbA_1c. In addition, increased hemoglobin and decreased serum creatinine over time also had an impact on the HbA_1c elevation over time in non-diabetic population.