SweetPea: A standard language for factorial experimental design
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Updated: Oct 25, 2025

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Sebastian Musslick1, Anastasia Cherkaev2, Ben Draut2
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA. musslick@princeton.edu.
Abstract:
Experimental design is a key ingredient of reproducible empirical research. Yet, given the increasing complexity of experimental designs, researchers often struggle to implement ones that allow them to measure their variables of interest without confounds. SweetPea ( https://sweetpea-org.github.io/ ) is an open-source declarative language in Python, in which researchers can describe their desired experiment as a set of factors and constraints. The language leverages advances in areas of computer science to sample experiment sequences in an unbiased way. In this article, we provide an overview of SweetPea's capabilities, and demonstrate its application to the design of psychological experiments. Finally, we discuss current limitations of SweetPea, as well as potential applications to other domains of empirical research, such as neuroscience and machine learning.
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