Related Experiment Video
Updated: Oct 25, 2025
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
Published on: November 17, 2023
Autologous nanofat injection in treatment of scars: A clinico-histopathological study
Mahmoud A Rageh1, Mohamed El-Khalawany1, Shady Mahmoud Attia Ibrahim1
1Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Background:
Scars are the unfortunate outcome of most injuries and some diseases. Its psychological impact on patients can deeply affect their quality of life.
Aim:
The aim of this study was to evaluate the efficacy of autologous nanofat injection in improving the aesthetic outcome of scars, combined with histopathological correlation of the response.
Patients And Methods:
Thirty patients with scars of different etiologies undergone one session of nanofat injection and evaluation was done 6 months after the session. Efficacy of treatment was assessed clinically using Vancouver scar scale by two independent blinded dermatologists and histopathologically using image analysis system.
Results:
The age of enrolled patients ranged from 18 to 40 years old. There was a statistically significant improvement on the total Vancouver scar scale regarding the height and pliability of the scars. Pathological evaluation showed an increase in epidermal thickness, increased number and density of collagen and elastic fibers along with neovascularization.
Conclusion:
Evidenced by clinical and pathological improvement, autologous nanofat injection is an effective strategy for treating scars of different etiologies.
