Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Label-free interferometry platform for drug response profiling of bioprinted tumor organoids at single-organoid resolution.

Nature protocols·2026

Same author

Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry-Mediated Enrichment of Extracellular Vesicles.

Advanced functional materials·2026

Same author

Single-cell protein activity analysis reveals aberrant myogenesis and IGF2-PI3K pathway dependencies in <i>MYOD1</i>-mutant rhabdomyosarcoma.

Science advances·2026

Same author

Advancing Preclinical Biology for Ewing Sarcoma: An International Effort.

Molecular cancer therapeutics·2025

Same author

Advancing Preclinical Biology for Ewing Sarcoma: An International Effort.

Molecular cancer therapeutics·2025

Same author

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Oct 25, 2025

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

Cervical organoids go viral.

Sara Sartini¹, Alice Soragni²

¹Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

|August 6, 2021

Summary

This summary is machine-generated.

Researchers developed a new method to create long-term patient-derived organoids from cervical cells. These organoids, from both healthy and cancerous tissues, offer new avenues for precision medicine and studying infections.

More Related Videos

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture

A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture

Published on: August 11, 2014

Related Experiment Videos

Last Updated: Oct 25, 2025

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture

A Video Protocol of Retroviral Infection in Primary Intestinal Organoid Culture

Published on: August 11, 2014

Area of Science:

Biomedical research
Stem cell technology
Organoid development

Background:

Cervical cancer research requires better models.
Patient-derived organoids offer a promising alternative to traditional cell cultures.
Generating long-term cervical organoids has been challenging.

Purpose of the Study:

To establish a versatile platform for generating long-term patient-derived organoids from cervical tissues.
To create both malignant and benign cervical organoids from endo- and ectocervix.
To explore applications in precision medicine and infection modeling.

Main Methods:

Utilized hysterectomy and Pap brush samples for organoid generation.
Developed a platform for long-term culture of cervical organoids.
Characterized organoids derived from various cervical tissue types.

Main Results:

Successfully generated long-term patient-derived organoids from cervical samples.
Established both malignant and benign organoid models from endo- and ectocervix.
Demonstrated the potential of these organoids for diverse applications.

Conclusions:

The developed platform provides a versatile tool for cervical organoid generation.
Patient-derived cervical organoids have significant potential in precision medicine.
These organoids are valuable for modeling cervical infections and diseases.