Macular integrity assessment microperimeter, Humphrey field analyzer and OCT in glaucoma practice: a correlation...

Area of Science:

• Ophthalmology
• Glaucoma Research
• Diagnostic Imaging

Background:

• Glaucoma diagnosis and monitoring rely on visual field testing and structural imaging.
• Comparing functional perimetry with structural optical coherence tomography (OCT) provides insights into disease progression.
• Primary open-angle glaucoma (POAG) and ocular hypertension (OHT) require accurate assessment of retinal sensitivity and optic nerve health.

Purpose of the Study:

• To compare and correlate retinal sensitivities from MAIA-MP and HFA 10-2 with OCT structural parameters in POAG and OHT.
• To evaluate the association between functional visual field tests and structural OCT measurements.
• To determine the utility of MAIA-MP and HFA 10-2 in assessing glaucoma-related structural changes.

Main Methods:

• Sixty-three participants (22 POAG, 20 OHT, 21 controls) underwent MAIA-MP and HFA 10-2 testing.
• OCT measurements included optic nerve head (ONH), peripapillary retinal nerve fibre layer thickness (PRNFLT), and ganglion cell inner plexiform layer thickness (GCIPLT).
• Pearson correlation and linear regression analyses assessed relationships between functional and structural parameters.

Main Results:

• MAIA-MP showed strong correlations with ONH, PRNFLT, and GCIPLT in POAG cases.
• HFA 10-2 demonstrated moderate correlations with ONH, PRNFLT, and GCIPLT in POAG cases.
• OHT cases exhibited weak correlations between HFA 10-2 and specific PRNFLT measurements.

Conclusions:

• MAIA-MP and HFA 10-2 functional parameters strongly correlate with OCT structural parameters in POAG.
• Both MAIA-MP and HFA 10-2 are valuable for central visual field assessment in glaucoma.
• MAIA-MP may offer advantages in patients with poor cooperation or reduced vision.