Properties and pharmacology of intravascular radiocontrast media

The new low osmolality contrast media iohexol, iopamidol and ioxaglate produce far smaller alterations in physiologic function and far less pain than do ionic monomer agents of the same iodine concentration. It appears from the clinical information currently available that they are likely to produce fewer serious side effects. The new agents are, however, still not perfect. They still must be used with care and attempts must be made to minimize injected doses and concentrations. In this observer's opinion a real danger exists that the substantial benefits of the new low osmolality agents will be misinterpreted as complete safety.