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Next Generation Protein Structure Predictions and Genetic Variant Interpretation.

Gaurav D Diwan1, Juan Carlos Gonzalez-Sanchez2, Gordana Apic3

  • 1BioQuant, Heidelberg University, Im Neuenheimer Feld 267, Heidelberg, Germany; Biochemistry Center (BZH), Heidelberg University, Im Neuenheimer Feld 328, Heidelberg, Germany. Electronic address: https://twitter.com/gddiwan.

Journal of Molecular Biology
|August 6, 2021
PubMed
Summary

Understanding genetic variants requires protein structures. While AlphaFold2 aids prediction, current human protein structure data may limit its impact on variant interpretation, necessitating further structure prediction efforts.

Keywords:
Alphafoldgenetic variantspredictionprotein functionprotein structure

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