Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DeepFixel: Crossing white matter fiber identification through spherical convolutional neural networks.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same author

Low-Cost and Detunable Wireless Resonator Glasses for Enhanced Eye MRI With Concurrent High-Quality Whole-Brain MRI.

Magnetic resonance in medicine·2026
Same author

White-Matter BOLD Mediates Time-Varying Cortico-Cortical Functional Connectivity.

bioRxiv : the preprint server for biology·2025
Same author

A practical prescription for magnetic resonance microscopy in a horizontal bore magnet.

Npj imaging·2025
Same author

Longitudinal measures of monkey brain structure and activity through adolescence predict cognitive maturation.

Nature neuroscience·2025
Same author

Low-Cost and Detunable Wireless Resonator Glasses for Enhanced Eye MRI with Concurrent High-Quality Whole-Brain MRI.

ArXiv·2025

Related Experiment Video

Updated: Oct 25, 2025

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.4K

Fiber tractography bundle segmentation depends on scanner effects, vendor effects, acquisition resolution, diffusion

Kurt G Schilling1, Chantal M W Tax2, Francois Rheault3

  • 1Department of Radiology & Radiological Science, Vanderbilt University Medical Center, Nashville, TN, United States; Vanderbilt Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States.

Neuroimage
|August 6, 2021
PubMed
Summary
This summary is machine-generated.

Investigating diffusion tractography, this study reveals that acquisition resolution significantly impacts white matter pathway segmentation reproducibility. Methodological choices in bundle segmentation introduce greater variability than scanner or protocol differences.

Keywords:
Bundle segmentationHarmonizationReproducibilityTractographyWhite matter

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.8K

Related Experiment Videos

Last Updated: Oct 25, 2025

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.4K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.5K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.8K

Area of Science:

  • Neuroimaging
  • Diffusion MRI
  • Tractography

Background:

  • Diffusion MRI enables brain white matter pathway analysis.
  • Bundle segmentation accuracy is crucial for microstructure studies.
  • Sources of variation in tractography are not fully understood.

Purpose of the Study:

  • To investigate six potential confounds affecting diffusion tractography bundle segmentation.
  • To assess the impact of these confounds on pathway reproducibility and features.
  • To compare the robustness of different bundle segmentation workflows.

Main Methods:

  • Evaluated scan repeats, scanners, vendors, resolution, diffusion schemes, and b-values.
  • Utilized four bundle segmentation workflows on two multi-subject databases.
  • Analyzed volume overlap, shape geometry, and microstructure features.

Main Results:

  • Acquisition resolution caused the most significant variation, followed by vendor and scanner effects.
  • Segmentation workflow choice introduced more variability than other confounds.
  • Deep white matter pathways showed consistent localization, while the gray/white matter interface exhibited variability.

Conclusions:

  • Harmonizing diffusion datasets requires careful consideration of acquisition and processing confounds.
  • Bundle segmentation workflow choice is a critical factor influencing results.
  • Tractography introduces variability beyond inherent noise and acquisition effects.