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Related Experiment Videos

Transient mood elevation associated with antidepressant drug decrease.

M Corral1, K Sivertz, B D Jones

  • 1Department of Psychiatry, UBC Health Sciences Centre Hospital, Vancouver.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|December 1, 1987
PubMed
Summary
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Antidepressant discontinuation can trigger mood elevation in some patients with unipolar depression. This case study explores a paradoxical mood boost from reducing desipramine, suggesting a rebound effect.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Antidepressant discontinuation can lead to mood disturbances, including hypomania and mania, in patients with unipolar depression.
  • Imipramine and desipramine are frequently implicated in these mood-related phenomena.
  • Transient mood elevation has been observed following antidepressant discontinuation.