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Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder
Ivy F Tso1, Cynthia Z Burton1, Carly A Lasagna1
1Department of Psychiatry, University of Michigan, Ann Arbor, United States.
Abstract:
Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.
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