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Drug repurposing of triazoles against mucormycosis using molecular docking: A short communication
Susmit Mhatre1, Vandana Patravale1
1Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Mumbai, Nathalal Parekh Marg, Matunga (E) Mumbai-19, Maharashtra, India.
Background:
Mucormycosis, a fungal infection caused by Rhizopus species is on the rise in COVID-19 patients as a result of their suppressed immunity. The current therapies include systemic administration of Amphotericin B.
Hypothesis And Method:
We screened several triazole broad-spectrum antifungal agents against the therapeutic target in mucormycosis using computational techniques like molecular docking and compared them with isavuconazole, an approved drug.
Result:
The study concluded that 4 triazole drugs, pramiconazole, itraconazole, posaconazole and ketoconazole were strong candidates to be further evaluated and developed as a treatment for mucormycosis.
Conclusion:
Novel topical and oral therapies could be developed from these drug leads.
