Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

8.1K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
8.1K
Apoptosis01:30

Apoptosis

12.4K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
12.4K
Autophagic Cell Death01:18

Autophagic Cell Death

3.7K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.7K
Necrosis01:16

Necrosis

5.1K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.1K
The Cell Cycle Control System01:28

The Cell Cycle Control System

4.3K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
4.3K
The Cell Cycle Control System02:11

The Cell Cycle Control System

12.9K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
12.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms and Ways to Overcome Acquired Resistance of Cancer Cells to Mcl-1 Antagonists.

Biochemistry. Biokhimiia·2025
Same author

Correction: Requirement for Serine-384 in Caspase-2 processing and activity.

Cell death & disease·2025
Same author

p62-dependent caspase-2 activation governs TDP-43 clearance and neuronal fate in ALS.

Cell death & disease·2025
Same author

Bcl-2 modifying factor (Bmf): "a mysterious stranger" in the Bcl-2 family proteins.

Cell death and differentiation·2025
Same author

Programmed cell death and tissue regeneration: a link that should be resolved.

Physiological reviews·2025
Same author

New hope for the world cancer day.

Biology direct·2025
Same journal

RETRACTED: Sabir et al. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. <i>Cancers</i> 2021, <i>13</i>, 3396.

Cancers·2026
Same journal

Correction: Adeluola et al. Chemoprevention of 4-NQO-Induced Oral Cancer by the Combination of Resveratrol and EGCG: In Vivo, In Silico and In Vitro Studies. <i>Cancers</i> 2026, <i>18</i>, 1098.

Cancers·2026
Same journal

Correction: Peñalver et al. Guidelines for Diagnosis, Treatment, and Follow-Up of Patients with Follicular Lymphoma-Spanish Lymphoma Group (GELTAMO) 2026. <i>Cancers</i> 2026, <i>18</i>, 395.

Cancers·2026
Same journal

Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

Cancers·2026
Same journal

Age-Stratified Long-Term Outcomes of Immune Checkpoint Inhibitors for Stage IV Melanoma and NSCLC in The Netherlands: A Population-Based Study.

Cancers·2026
Same journal

Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.

Cancers·2026
See all related articles

Related Experiment Video

Updated: Oct 25, 2025

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.4K

Anastasis: Return Journey from Cell Death.

Victoria Zaitceva1, Gelina S Kopeina1, Boris Zhivotovsky1,2

  • 1Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.

Cancers
|August 7, 2021
PubMed
Summary
This summary is machine-generated.

Cells can reverse death processes, even after mitochondrial damage, through a phenomenon called anastasis. This recovery, triggered by signal removal, challenges the inevitability of cell death and offers new therapeutic avenues.

Keywords:
anastasisapoptosismitochondriastresssurvival

More Related Videos

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

18.2K
Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
10:29

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Published on: March 16, 2020

8.1K

Related Experiment Videos

Last Updated: Oct 25, 2025

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.4K
Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

18.2K
Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
10:29

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Published on: March 16, 2020

8.1K

Area of Science:

  • Cellular biology
  • Apoptosis research
  • Mitochondrial dynamics

Background:

  • Mitochondrial integrity disruption and release of proapoptotic factors were considered irreversible triggers of cell death.
  • Established dogma suggested that once mitochondria are compromised, cell death is inevitable.
  • Recent findings challenge this long-standing belief in cell death pathways.

Purpose of the Study:

  • To critically review the current understanding of cell death reversal mechanisms.
  • To explore the phenomenon of anastasis, where cells recover from death signals.
  • To discuss methods for detecting anastasis and the role of intracellular signaling.

Main Methods:

  • Literature review and critical analysis of existing research on cell death and recovery.
  • Discussion of methodologies employed to identify and study anastasis.
  • Examination of signaling pathways involved in stimulating anastasis.

Main Results:

  • Cellular recovery (anastasis) is possible even after initial mitochondrial damage and proapoptotic protein release.
  • Removal of death signals can initiate a reversal of the cell death cascade.
  • Signaling from various intracellular compartments plays a crucial role in promoting anastasis.

Conclusions:

  • The concept of inevitable cell death upon mitochondrial disruption is challenged by the phenomenon of anastasis.
  • Anastasis represents a significant cellular survival mechanism previously underestimated.
  • Further research into anastasis mechanisms and signaling could yield novel therapeutic strategies.