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Anastasis: Return Journey from Cell Death

Victoria Zaitceva1, Gelina S Kopeina1, Boris Zhivotovsky1,2

  • 1Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.

Cancers
|August 7, 2021
PubMed

Insights

Cells can reverse death processes, even after mitochondrial damage, through a phenomenon called anastasis. This recovery, triggered by signal removal, challenges the inevitability of cell death and offers new therapeutic avenues.

Area of Science:

  • Cellular biology
  • Apoptosis research
  • Mitochondrial dynamics

Background:

  • Mitochondrial integrity disruption and release of proapoptotic factors were considered irreversible triggers of cell death.
  • Established dogma suggested that once mitochondria are compromised, cell death is inevitable.
  • Recent findings challenge this long-standing belief in cell death pathways.

Purpose of the Study:

  • To critically review the current understanding of cell death reversal mechanisms.
  • To explore the phenomenon of anastasis, where cells recover from death signals.
  • To discuss methods for detecting anastasis and the role of intracellular signaling.

Main Methods:

  • Literature review and critical analysis of existing research on cell death and recovery.
  • Discussion of methodologies employed to identify and study anastasis.
  • Examination of signaling pathways involved in stimulating anastasis.

Main Results:

  • Cellular recovery (anastasis) is possible even after initial mitochondrial damage and proapoptotic protein release.
  • Removal of death signals can initiate a reversal of the cell death cascade.
  • Signaling from various intracellular compartments plays a crucial role in promoting anastasis.

Conclusions:

  • The concept of inevitable cell death upon mitochondrial disruption is challenged by the phenomenon of anastasis.
  • Anastasis represents a significant cellular survival mechanism previously underestimated.
  • Further research into anastasis mechanisms and signaling could yield novel therapeutic strategies.
Keywords:
anastasisapoptosismitochondriastresssurvival

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