Related Experiment Video

Updated: Oct 25, 2025

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies
06:27

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies

Published on: August 8, 2019

9.2K

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

Tsai-Mu Cheng1,2, Wong-Jin Chang1, Hsiu-Yi Chu1

  • 1Graduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.

Cells
|August 7, 2021
PubMed

Insights

Integrin αvβ3 is a key target in cancer therapy. Nanomaterials like RGD peptide, PLGA-tetrac derivatives (NDAT), and nanoresveratrol show potential for targeting this receptor to inhibit cancer proliferation and metastasis.

Area of Science:

  • Oncology
  • Cell Biology
  • Nanomedicine

Background:

  • Integrin αvβ3 is a cell surface receptor crucial for cancer cell proliferation and metastasis.
  • CEACAM6 activates integrin FAK, promoting cancer progression.
  • Targeting integrin αvβ3 signaling pathways offers a promising strategy for cancer treatment.

Purpose of the Study:

  • To review and evaluate the use of nanomaterial carriers targeting integrin αvβ3 for cancer therapy.
  • To explore the potential of RGD peptide, PLGA-tetrac derivatives (NDAT), and nanoresveratrol.

Main Methods:

  • Literature review of studies investigating integrin αvβ3 as a therapeutic target.
  • Evaluation of nanomaterial-based drug delivery systems for cancer treatment.
  • Analysis of compounds like tetrac and resveratrol in targeting integrin αvβ3.

Main Results:

  • Integrin αvβ3 plays a significant role in cancer cell signaling, proliferation, and metastasis.
  • Specific ligands and compounds (tetrac, resveratrol) bind to integrin αvβ3, inhibiting cancer growth.
  • Nanotechnology enhances the delivery and efficacy of therapeutic agents targeting integrin αvβ3.

Conclusions:

  • Nanomaterial carriers, including RGD peptide, NDAT, and nanoresveratrol, demonstrate potentiation for targeting integrin αvβ3 in cancer therapies.
  • Targeting integrin αvβ3 with advanced nanomedicine approaches holds significant promise for future cancer treatment strategies.
Keywords:
NDATRGDdrug-delivery systemintegrin αvβ3nanomaterialresveratrol

More Related Videos

Three-Dimensional 3D Tumor Spheroid Invasion Assay12:19

Three-Dimensional 3D Tumor Spheroid Invasion Assay

Published on: May 1, 2015

58.4K
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

9.9K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.1K
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
4.1K
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
4.5K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.2K