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Updated: Oct 25, 2025

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Martina Rossi1, Kotb Abdelmohsen1

  • 1Laboratory of Genetics and Genomics, RNA Regulation Section, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA.

Cells
|August 7, 2021
PubMed

Insights

Senotherapeutics offer new ways to combat aging by targeting senescent cells. This review focuses on senolysis, using surface biomarkers to eliminate these cells and treat age-related diseases.

Area of Science:

  • Gerontology and Cellular Biology
  • Biomedical Sciences
  • Molecular Biology

Background:

  • Cellular senescence contributes to age-associated diseases and physiological decline.
  • Senotherapeutics, including senomorphics and senolytics, aim to mitigate these effects.
  • Senolytics target senescent cells for clearance, reducing inflammation and promoting immune removal.

Purpose of the Study:

  • To review current knowledge on senolysis, a strategy to eliminate senescent cells.
  • To highlight novel surface biomarkers of cellular senescence.
  • To discuss the potential of these biomarkers as targets for senotherapeutics.

Main Methods:

  • Literature review of recent research on senolysis and cellular senescence.
  • Focus on identifying and analyzing surface biomarkers specific to senescent cells.
  • Discussion of the therapeutic implications of targeting these biomarkers.

Main Results:

  • Senescent cells exhibit unique surface proteins crucial for their survival.
  • These surface proteins represent promising targets for senolytic drugs.
  • Targeting surface biomarkers can enhance the selective elimination of senescent cells.

Conclusions:

  • Targeting surface biomarkers is a viable senotherapeutic strategy.
  • Further research into these biomarkers could lead to effective treatments for age-related conditions.
  • Senolysis via surface biomarker targeting holds significant promise for improving healthspan.
Keywords:
senescencesenescent cell clearancesenolysissenolyticssenostaticsenotherapeuticssenotherapysurface proteinssurfaceome

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