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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

The Vascular Circadian Clock in Chronic Kidney Disease

Søren Egstrand1,2, Maria L Mace2, Klaus Olgaard2

  • 1Nephrological Department B, Herlev Hospital, University of Copenhagen, 2730 Copenhagen, Denmark.

Cells
|August 7, 2021
PubMed

Insights

Chronic kidney disease (CKD) disrupts vascular circadian rhythms, impacting cardiovascular health. This study reveals altered clock gene expression in the aorta, linking CKD to vascular pathology.

Area of Science:

  • Cardiovascular Science
  • Nephrology
  • Chronobiology

Background:

  • Chronic kidney disease (CKD) is linked to high cardiovascular mortality.
  • Circadian rhythms (CR) influence vascular function; their disruption contributes to cardiovascular diseases.
  • Uremia in CKD may affect the brain's master circadian pacemaker and peripheral clocks.

Purpose of the Study:

  • To investigate the impact of CKD on the intrinsic circadian clock within the vasculature.
  • To understand the role of vascular circadian clock disruption in uremic vasculopathy.

Main Methods:

  • Analysis of core circadian clock gene expression in the aorta of CKD models.
  • Assessment of molecular clock function in vascular tissues under uremic conditions.

Main Results:

  • Expression of core circadian clock genes in the aorta is significantly disrupted in CKD.
  • CKD alters the molecular circadian clock within the vasculature.

Conclusions:

  • Circadian clock system disruption in the vasculature is a key factor in the pathology of uremic vasculopathy.
  • Targeting vascular circadian rhythms may offer new therapeutic strategies for CKD patients.

Keywords:
ICAM-1VCAM-1adhesion moleculescardiovascular diseaseccl2inflammationthrombomodulinuremiavascular calcification

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