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MicroRNAs, Multiple Sclerosis, and Depression

Hsiuying Wang1

  • 1Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

International Journal of Molecular Sciences
|August 7, 2021
PubMed

Insights

This review explores common microRNA biomarkers linking multiple sclerosis (MS) and major depression (MD). Identifying shared biomarkers may illuminate the complex relationship between these two conditions.

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system disease with various courses (RRMS, PPMS, SPMS).
  • Major depression (MD) frequently co-occurs with MS, affecting up to 50% of patients.
  • The MS-MD comorbidity is influenced by neuroinflammation, gut dysbiosis, oxidative stress, and neuroendocrine factors.

Purpose of the Study:

  • To review common microRNA (miRNA) biomarkers associated with both multiple sclerosis and major depression.
  • To explore the potential role of miRNA regulation in the comorbidity between MS and MD.

Main Methods:

  • Literature review of studies investigating MS and MD.
  • Analysis of common microRNA biomarkers identified in both conditions.

Main Results:

  • Several microRNA biomarkers are implicated in both MS and MD.
  • These shared biomarkers suggest a potential molecular link between the two diseases.

Conclusions:

  • MicroRNAs represent promising biomarkers for understanding the MS-MD comorbidity.
  • Further research into common miRNA biomarkers could reveal novel therapeutic targets.
Keywords:
biomarkerdepressionmicroRNAmultiple sclerosistreatment

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