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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs, Multiple Sclerosis, and Depression.

Hsiuying Wang1

  • 1Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

International Journal of Molecular Sciences
|August 7, 2021
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Summary
This summary is machine-generated.

This review explores common microRNA biomarkers linking multiple sclerosis (MS) and major depression (MD). Identifying shared biomarkers may illuminate the complex relationship between these two conditions.

Keywords:
biomarkerdepressionmicroRNAmultiple sclerosistreatment

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Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system disease with various courses (RRMS, PPMS, SPMS).
  • Major depression (MD) frequently co-occurs with MS, affecting up to 50% of patients.
  • The MS-MD comorbidity is influenced by neuroinflammation, gut dysbiosis, oxidative stress, and neuroendocrine factors.

Purpose of the Study:

  • To review common microRNA (miRNA) biomarkers associated with both multiple sclerosis and major depression.
  • To explore the potential role of miRNA regulation in the comorbidity between MS and MD.

Main Methods:

  • Literature review of studies investigating MS and MD.
  • Analysis of common microRNA biomarkers identified in both conditions.

Main Results:

  • Several microRNA biomarkers are implicated in both MS and MD.
  • These shared biomarkers suggest a potential molecular link between the two diseases.

Conclusions:

  • MicroRNAs represent promising biomarkers for understanding the MS-MD comorbidity.
  • Further research into common miRNA biomarkers could reveal novel therapeutic targets.