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Antimicrobial Peptides with Antibacterial Activity against Vancomycin-Resistant Staphylococcus aureus Strains:

Isabella Hernández-Aristizábal1, Iván Darío Ocampo-Ibáñez1

  • 1Research Group of Microbiology, Industry and Environment, Faculty of Basic Sciences, Universidad Santiago de Cali, Cali 760035, Colombia.

International Journal of Molecular Sciences
|August 7, 2021
PubMed

Insights

Antimicrobial peptides (AMPs) show promise as alternatives to antibiotics against resistant bacteria. This review details AMPs effective against vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-intermediate S. aureus (VISA).

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Antibiotic resistance in Staphylococcus aureus, including vancomycin-resistant (VRSA) and vancomycin-intermediate (VISA) strains, poses a significant global health threat.
  • The ineffectiveness of current antibiotics necessitates the development of novel therapeutic strategies to combat these resistant infections.
  • Antimicrobial peptides (AMPs) are emerging as a promising alternative due to their broad-spectrum activity and unique mechanisms of action.

Purpose of the Study:

  • To conduct a comprehensive systematic review of AMPs with demonstrated antibacterial activity against VRSA and VISA strains.
  • To analyze the classification, origin, physicochemical properties, structural characteristics, and mechanisms of action of these AMPs.
  • To consolidate existing research on AMPs as a potential therapeutic approach for challenging Staphylococcus aureus infections.

Main Methods:

  • Systematic literature search for studies reporting AMPs effective against VRSA and VISA.
  • Inclusion of research on natural, artificial, and synthetic AMPs.
  • Analysis of data regarding peptide characteristics and antibacterial mechanisms.

Main Results:

  • A wide array of AMPs, including natural, synthetic, and artificial variants, exhibit potent activity against VRSA and VISA.
  • These AMPs possess diverse physicochemical and structural properties influencing their efficacy.
  • Various mechanisms of action are proposed, often involving disruption of bacterial membranes.

Conclusions:

  • AMPs represent a highly promising alternative therapeutic strategy for combating infections caused by vancomycin-resistant Staphylococcus aureus.
  • Further research and development of AMPs could lead to novel treatments for multidrug-resistant bacterial infections.
  • This review provides a foundational resource for understanding AMPs against VRSA and VISA, highlighting their clinical potential.
Keywords:
antimicrobial peptidesvancomycin-intermediate resistant Staphylococcus aureusvancomycin-resistant Staphylococcus aureus

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