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Role of Melatonin in Angiotensin and Aging
Ahmet Ozer Sehirli1, Serkan Sayıner2, Ugochukwu Chukwunyere3
1Department of Pharmacology, Faculty of Dentistry, Near East University, North Cyprus, Mersin 10, Nicosia 99138, Turkey.
Abstract:
The cellular utilization of oxygen leads to the generation of free radicals in organisms. The accumulation of these free radicals contributes significantly to aging and several age-related diseases. Angiotensin II can contribute to DNA damage through oxidative stress by activating the NAD(P)H oxidase pathway, which in turn results in the production of reactive oxygen species. This radical oxygen-containing molecule has been linked to aging and several age-related disorders, including renal damage. Considering the role of angiotensin in aging, melatonin might relieve angiotensin-II-induced stress by enhancing the mitochondrial calcium uptake 1 pathway, which is crucial in preventing the mitochondrial calcium overload that may trigger increased production of reactive oxygen species and oxidative stress. This review highlights the role and importance of melatonin together with angiotensin in aging and age-related diseases.
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