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Still's Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?

Perrine Dusser1,2, Isabelle Koné-Paut1,2

  • 1Paediatric Rheumatology Department, Université Paris-Saclay, APHP, Bicêtre Hospital, 94270 Le Kremlin-Bicêtre, France.

Journal of Clinical Medicine
|August 7, 2021
PubMed

Insights

Still's disease and Kawasaki disease (KD) are cytokine storm syndromes. These conditions may represent a common spectrum influenced by genetic factors affecting the adaptive immune response.

Area of Science:

  • Immunology
  • Rheumatology
  • Pediatrics

Background:

  • Still's disease and Kawasaki disease (KD) are cytokine storm syndromes.
  • Both are linked to excessive innate immune system activation.

Purpose of the Study:

  • To explore the connection between Still's disease and KD.
  • To propose a unifying concept for these distinct conditions.

Main Methods:

  • Comparative analysis of clinical and pathophysiological features.
  • Review of existing literature and theoretical framework.

Main Results:

  • Significant clinical and pathophysiological similarities exist between Still's disease and KD.
  • These diseases may exist on a spectrum of immune dysregulation.

Conclusions:

  • Still's disease and KD share a common pathophysiological basis.
  • Subtle differences in adaptive immune responses, potentially genetically influenced, may differentiate their clinical outcomes.

Keywords:
Kawasaki diseaseStill’s diseasedisease overlapinterleukin-1

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