Calculated Plasma Volume Status Is Associated with Adverse Outcomes in Patients Undergoing Transcatheter Aortic Valve...

Area of Science:

• Cardiology
• Cardiovascular Research
• Medical Diagnostics

Background:

• Plasma volume status (PVS) quantifies fluid overload by comparing estimated plasma volume (ePV) to ideal plasma volume (iPV).
• PVS is a known prognostic indicator in heart failure patients.
• This study examines the prognostic significance of PVS in the context of transcatheter aortic valve implantation (TAVI).

Purpose of the Study:

• To investigate the prognostic impact of calculated plasma volume status (PVS) in patients undergoing transcatheter aortic valve implantation (TAVI).
• To determine if PVS is associated with adverse outcomes, specifically all-cause mortality or heart failure hospitalization, within one year post-TAVI.

Main Methods:

• An observational study prospectively enrolled 859 TAVI patients.
• Receiver operating characteristic curve analysis identified an optimal PVS cutoff of -5.4%.
• The primary endpoint was a composite of all-cause mortality or heart failure hospitalization within 1 year.

Main Results:

• A PVS of ≥ -5.4% (indicating congestion) was observed in 535 patients, while 324 had a PVS < -5.4% (no congestion).
• The primary endpoint occurred significantly more often in patients with PVS ≥ -5.4% (22.6%) compared to those with PVS < -5.4% (13.0%, p < 0.001).
• Multivariable analysis confirmed PVS as a significant predictor of the primary endpoint (HR 1.53, p = 0.026).

Conclusions:

• Elevated PVS serves as a marker for subclinical congestion.
• Higher PVS is significantly associated with increased risk of all-cause mortality and heart failure hospitalization within one year after TAVI.
• PVS is a valuable prognostic tool for TAVI patients.