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Updated: Oct 25, 2025

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
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Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction

Akisato Nishigaki1, Yuhuko Ichikawa2, Minoru Ezaki2

  • 1Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan.

Journal of Clinical Medicine
|August 7, 2021
PubMed

Insights

Plasma sCLEC-2 and D-dimer levels can help diagnose acute cerebral infarction (ACI). These markers aid in differentiating between atherosclerotic and cardioembolic ACI, improving diagnostic accuracy.

Area of Science:

  • Biochemistry
  • Neurology
  • Cardiology

Background:

  • Acute cerebral infarction (ACI) encompasses cardiogenic and atherosclerotic subtypes, posing diagnostic challenges.
  • Distinguishing between these ACI types is crucial for appropriate treatment selection.

Purpose of the Study:

  • To evaluate the utility of plasma soluble C-type lectin-2 (sCLEC-2) and D-dimer levels in diagnosing ACI.
  • To differentiate between atherosclerotic and cardioembolic ACI using these biomarkers.

Main Methods:

  • Plasma sCLEC-2 and D-dimer levels were quantified using the STACIA system.
  • Biomarker levels were compared between different ACI subtypes and control groups.

Main Results:

  • Significantly elevated plasma sCLEC-2 levels were observed in ACI patients, particularly with atherosclerotic or lacunar ACI.
  • Elevated plasma D-dimer levels were prominent in cardioembolic ACI.
  • Higher sCLEC-2/D-dimer ratios were found in atherosclerotic/lacunar ACI compared to cardioembolic ACI.

Conclusions:

  • Combined measurement of plasma sCLEC-2 and D-dimer shows promise for ACI diagnosis.
  • These biomarkers can aid in differentiating between atherosclerotic and cardioembolic ACI.
Abstract

Keywords:
acute cerebral infarction (ACI)atherosclerotic ACIcardioembolic ACIplatelet activationsCLEC-2

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