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Decrease in serum prolactin during bromocriptine-induced pregnancy and subsequent restoration of reproductive

K Seki1, K Kato

  • 1Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.

Endocrinologia Japonica
|October 1, 1987
PubMed
Summary

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Pregnancy with bromocriptine treatment can restore menstruation and fertility in women with hyperprolactinemia. Lower prolactin (PRL) levels after pregnancy correlate with spontaneous conception, indicating restored reproductive function.

Area of Science:

  • Reproductive Endocrinology
  • Clinical Pharmacology

Background:

  • Hyperprolactinemia often causes amenorrhea (absence of menstruation) and infertility.
  • Bromocriptine is a dopamine agonist used to treat hyperprolactinemia.

Purpose of the Study:

  • To investigate the long-term reproductive outcomes in women with hyperprolactinemia and amenorrhea after bromocriptine-induced pregnancies.
  • To identify factors predicting the return of spontaneous menstruation and fertility post-pregnancy.

Main Methods:

  • Follow-up study of 22 women with hyperprolactinemia and amenorrhea after bromocriptine-induced pregnancies.
  • Serial measurement of serum prolactin (PRL) levels before, during, and after pregnancy and bromocriptine treatment.
  • Assessment of menstruation return and subsequent spontaneous conception.

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Main Results:

  • Menstruation returned in 9/22 patients post-pregnancy; 5 conceived spontaneously.
  • Lower post-weaning PRL levels were significantly associated with spontaneous conception.
  • A decrease in PRL levels during the second or third trimester of pregnancy was observed in 7/11 patients, and 3 of these later conceived spontaneously.

Conclusions:

  • Bromocriptine-induced pregnancies can lead to the restoration of reproductive function in some women with hyperprolactinemia.
  • Decreased prolactin levels during pregnancy may predict lower PRL levels post-weaning, facilitating the return of menstruation and fertility.