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Updated: Oct 25, 2025
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Coronary artery revascularizations and cognitive decline - A systematic review
Laura Lappalainen1, Blair Rajamaki2, Anna-Maija Tolppanen2
1School of Pharmacy, University of Eastern Finland, FI, Kuopio, Finland.
Insights
Coronary artery revascularization procedures like CABG and PCI do not have clear links to cognitive decline or dementia. More research is needed to understand the long-term cognitive effects of these cardiovascular interventions.
Area of Science:
- Cardiology
- Neurology
- Medical Research
Background:
- Coronary artery disease (CAD) is recognized as a risk factor for cognitive decline.
- Understanding the impact of cardiovascular interventions on cognitive function is crucial for patient care.
Purpose of the Study:
- To systematically review recent literature on the association between coronary artery revascularization procedures and cognitive decline or dementia.
- To identify evidence gaps regarding long-term cognitive outcomes after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI).
Main Methods:
- Systematic literature search of Pubmed, Scopus, and CINAHL (EBSCO) databases.
- Inclusion criteria focused on studies comparing CAD patients undergoing CABG or PCI with other treatments, assessing cognitive decline or dementia outcomes.
- Search conducted for articles published between January 2009 and September 2020.
Main Results:
- Only four out of 680 reviewed articles met the inclusion criteria.
- The results regarding the association between revascularization and cognitive outcomes were inconsistent.
- Outcome measurements for cognitive decline and dementia were heterogeneous across the included studies.
Conclusions:
- There is a significant evidence gap in understanding the long-term cognitive outcomes following coronary artery revascularization.
- Further research is necessary to elucidate the effects of CABG and PCI on cognition and dementia risk.
- Establishing long-term cognitive effects would enhance the understanding of the overall benefits of these cardiovascular procedures.
Abstract:
Coronary artery disease (CAD) is a risk factor for cognitive decline. The aim of this study was to systematically review recent literature on whether coronary artery revascularizations are associated to cognitive decline and dementia. Pubmed, Scopus, and CINAHL (EBSCO) were searched systematically from January 2009 to September 2020. Studies were conducted on persons with CAD undergoing coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) procedure compared to other coronary artery disease treatments, and the outcome was cognitive decline or dementia. Altogether four of the 680 reviewed articles met inclusion criteria. Results were inconsistent, and the outcome measurements heterogeneous between studies. Our findings indicate an evidence gap in the current understanding of long-term outcomes following coronary artery revascularization. However, evidence of long-term effects on cognition would complement our understanding of their benefits. There is a need for more studies on long-term cognitive outcomes after coronary artery revascularizations.
