[Distribution of prazosin and its metabolites in animal organs during chronic administration]

The distribution of prazosin and its metabolites in organs of rabbits and rats during oral long-term administration at different doses was studied. Prazosin was shown to be accumulated in the animals' organs. Three metabolites of prazosin one of which was identified were detected in the blood serum, bile and organs of the animals. The contents of prazosin and the metabolites in organs and tissues were non-linearly related to the dose.