[Effects of dibasol and levamisole on the microsomal enzyme system]

It was shown that single doses of levamisole (10 mg/kg) and dibasole (50 and 100 mg/kg) suppressed the activity of cytochrome P-450 that was indicated by an increase of hexenal-induced sleep in mice. Administration of dibasole (100 mg/kg) three times was not followed by a significant change in the sleep duration. It was also established that dibasole administered at the concentration of 5 10(-4) M suppressed approximately by 50% the activity of aminopyrindemethylase and benzopyrenmonooxygenase and exerted no influence on methylcholantrene-induced activity of benzpyrenmonooxygenase.