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Recent advances in chitosan-based layer-by-layer biomaterials and their biomedical applications
Biao Hu1, Yuchun Guo2, Houbin Li3
1School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.
Carbohydrate Polymers
|August 8, 2021
Summary
Recent advances in chitosan-based biomaterials utilize layer-by-layer (LBL) assembly for biomedical applications. This review covers LBL driving forces, material forms, and uses in antimicrobial, drug delivery, wound healing, and tissue engineering.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Chitosan-based biomaterials are extensively researched for biomedical applications.
- Layer-by-layer (LBL) assembly is a key technology for developing these materials.
- Recent technological advancements have enabled new chitosan-based LBL materials.
Purpose of the Study:
- To review recent advances in chitosan-based biomaterials produced by LBL assembly.
- To discuss the driving forces behind LBL assembly for chitosan.
- To summarize the various forms and applications of these biomaterials.
Main Methods:
- Review of scientific literature on chitosan-based LBL biomaterials.
- Analysis of driving forces in LBL assembly (electrostatic interactions, hydrogen bonds, Schiff base linkages).
- Categorization of LBL materials by form (films, coatings, capsules, fibers).
Main Results:
- Chitosan-based LBL materials have shown significant potential in various biomedical fields.
- Different driving forces enable tailored material properties.
- Diverse material forms (films, capsules, fibers) have been developed.
Conclusions:
- Chitosan-based LBL biomaterials offer versatile solutions for biomedical challenges.
- Continued research is expanding their applications in drug delivery, antimicrobial treatments, wound healing, and tissue engineering.
