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Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
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Alginate modification via click chemistry for biomedical applications
Yaling Deng1, Amin Shavandi2, Oseweuba Valentine Okoro2
1College of Intelligent Science and Control Engineering, Jinling Institute of Technology, Nanjing 211169, China.
Carbohydrate Polymers
|August 8, 2021
Summary
Click chemistry enhances alginate biopolymers, improving stability and properties for applications like drug delivery and tissue regeneration. This review explores various click reactions and their impact on alginate material development.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Chemical Engineering
Background:
- Alginate biopolymers offer biocompatibility, degradability, and non-toxicity.
- Poor stability limits alginate's application range.
- Click chemistry provides efficient, selective, and simple modification methods.
Purpose of the Study:
- To review the use of click chemistry in developing alginate-based materials.
- To discuss various click chemistry reactions applicable to alginate modification.
- To highlight the impact of click chemistry on alginate properties and applications.
Main Methods:
- Review of literature on click chemistry applications in alginate modification.
- Categorization of click chemistry reactions: cycloadditions (CuAAC, SPAAC, IEDDA), thiol-ene/yne, oxime-based, and others.
- Discussion of alginate functionalization strategies and resulting property changes.
Main Results:
- Click chemistry significantly enhances the physical and chemical properties of alginate.
- Modified alginate exhibits improved mechanical strength and tunable biochemical/biological characteristics.
- Various click chemistry techniques successfully functionalize alginate for diverse material designs.
Conclusions:
- Click chemistry is a powerful tool for overcoming alginate's limitations, particularly stability.
- Alginate-based materials modified via click chemistry show promise in wound dressing, drug/protein delivery, tissue regeneration, and 3D bioprinting.
- This review offers insights for rational design and expanded applications of click chemistry-modified alginates.
