Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Glucose Transporters

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:

Histology of the Small Intestine

Histology of the Small Intestine

The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Thrombocytosis in a 56 year-old woman].

La Revue de medecine interne·2021

Same author

[Surgical treatment of an auto-immune hemolytic anemia].

La Revue de medecine interne·2018

Same author

[Tracheotomy for laryngeal tuberculosis].

Medecine et maladies infectieuses·2017

Same author

[Breast lesions as the presenting feature of giant cell arteritis].

La Revue de medecine interne·2016

Same author

[Primary Sjögren's syndrome revealing cerebellar syndrome].

Revue neurologique·2015

Same author

Nasal lavage CCL24 levels correlate with eosinophils trafficking and symptoms in chronic sino-nasal eosinophilic inflammation.

Rhinology·2011

Same journal

[Abdominal pain, fever and arthralgia in a 49-year-old woman].

La Revue de medecine interne·2026

Same journal

[Cardiorespiratory functional disorders: A transnosologic approach].

La Revue de medecine interne·2026

Same journal

[Diagnostic evaluation for suspected polycythemia].

La Revue de medecine interne·2026

Same journal

Heart involvements in systemic sclerosis beyond pulmonary hypertension: From conduction, rhythm and function defects to coronary artery disease.

La Revue de medecine interne·2026

Same journal

[Acute intermittent porphyria: When diagnostic errance jeopardizes patient health].

La Revue de medecine interne·2026

Same journal

Autosomal dominant polycystic kidney disease: Current perspectives in 2026.

La Revue de medecine interne·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 25, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Selective IgA deficiency].

L Luca¹, C Beuvon², M Puyade¹

¹Service de médecine interne, maladies infectieuses et tropicales, centre hospitalier universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers cedex, France.

La Revue De Medecine Interne

|August 8, 2021

Summary

This summary is machine-generated.

Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency, often asymptomatic. Management focuses on individual needs, vaccinations, and treating complications like infections or autoimmune disorders.

Keywords:

Allergies et immunologie Allergy and immunology Auto-immunité Autoimmunity Déficit en IgA Déficits immunitaires primitifs IgA deficiency Infections Primary immunodeficiency diseases

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Related Experiment Videos

Last Updated: Oct 25, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Area of Science:

Immunology
Clinical Medicine

Background:

Selective IgA deficiency (SIgAD) is defined by low serum IgA (<0.07g/L) in individuals over 4 years old, with normal IgG, IgM, and vaccine responses.
It is the most prevalent primary immunodeficiency in Europe, affecting approximately 1 in 600 individuals in France.
A significant majority (75-90%) of patients with SIgAD remain asymptomatic.

Purpose of the Study:

To define Selective IgA deficiency (SIgAD) based on European Society for Immunodeficiencies (ESID) criteria.
To outline the clinical manifestations and management strategies for SIgAD.
To emphasize the importance of an interdisciplinary approach for patient care.

Main Methods:

Diagnostic criteria involve serum IgA levels below 0.07g/L, normal IgG and IgM, and adequate vaccine responses, excluding secondary causes.
Clinical data and potential complications associated with SIgAD were reviewed.
Management strategies were assessed based on patient's clinical status and comorbidities.

Main Results:

Common complications include recurrent respiratory and gastrointestinal infections, autoimmune conditions, and allergic reactions.
Anaphylaxis can occur if IgA-containing blood products are administered.
Partial IgA deficiency, with IgA levels above 0.07g/L but below age-specific norms, is also recognized.

Conclusions:

There is no specific cure for SIgAD; management is individualized.
Asymptomatic patients require up-to-date vaccinations.
Treatment may include prophylactic antibiotics for recurrent infections or immunoglobulin replacement therapy for those with concomitant IgG subclass deficiency.