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Microbiota and sleep: awakening the gut feeling
Paromita Sen1, Alicia Molinero-Perez1, Kenneth J O'Riordan1
1APC Microbiome Ireland, University College Cork, Cork, Ireland.
Trends in Molecular Medicine
|August 8, 2021
Summary
The gut microbiota influences sleep through the microbiota-gut-brain axis. Modulating gut bacteria may offer new strategies for improving sleep quality and treating sleep disorders.
Area of Science:
- Neuroscience
- Microbiology
- Sleep Science
Background:
- Lifestyle and environmental factors impact sleep.
- The gut microbiota plays a role in regulating brain function and behavior.
- The microbiota-gut-brain axis is an emerging area of research.
Purpose of the Study:
- To explore the influence of the microbiota-gut-brain axis on sleep.
- To summarize molecular mechanisms of sleep-microbiome interactions.
- To discuss the role of the gut microbiota in sleep disorders.
Main Methods:
- Literature review of existing studies on the microbiota-gut-brain axis and sleep.
- Analysis of molecular pathways connecting gut microbes and sleep regulation.
- Examination of evidence for microbiota alterations in sleep disorders.
Main Results:
- The gut microbiota affects sleep both directly and indirectly.
- Specific molecular mechanisms link gut bacteria to sleep patterns.
- Alterations in the microbiota-gut-brain axis are observed in various sleep disorders.
Conclusions:
- The gut microbiota is a significant factor in sleep regulation.
- Targeting the gut microbiota presents a potential therapeutic avenue for sleep disturbances.
- Further research into microbiota-gut-brain interactions is warranted for sleep health.
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