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Related Experiment Video

Updated: Oct 25, 2025

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White adipose tissue dysfunction in obesity and aging.

Marjorie Reyes-Farias1, Julia Fos-Domenech2, Dolors Serra3

  • 1Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain; Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain.

Biochemical Pharmacology
|August 8, 2021
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Summary

Obesity and aging promote metabolic diseases through chronic adipose tissue inflammation. This review explores shared features and immune cell changes in white adipose tissue during these conditions.

Keywords:
Adipose tissueAgingImmune cellsObesity

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Area of Science:

  • Metabolic diseases
  • Immunology
  • Aging research

Background:

  • Obesity and aging are linked to metabolic diseases like type 2 diabetes and cardiovascular disease.
  • Chronic low-grade inflammation in adipose tissue is a key mechanism driving disease progression.
  • Both conditions alter adipose tissue, promoting a pro-inflammatory immune cell phenotype.

Purpose of the Study:

  • To review common characteristics of obesity and aging.
  • To examine alterations in white adipose tissue and resident immune cells.
  • To focus on metabolic derangements, inflammation, and remodeling in adipose tissue.

Main Methods:

  • Literature review of studies on obesity, aging, and metabolic diseases.
  • Analysis of shared features between obesity and aging.
  • Examination of adipose tissue and immune cell alterations.

Main Results:

  • Obesity and aging share features like increased visceral adipose tissue and reduced lifespan.
  • Both conditions induce adipose tissue remodeling and inflammation.
  • Immune cells within adipose tissue adopt a pro-inflammatory state.

Conclusions:

  • Shared mechanisms in obesity and aging contribute to metabolic dysfunction.
  • Adipose tissue inflammation and remodeling are critical in disease development.
  • Understanding these commonalities can inform therapeutic strategies.