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Published on: May 18, 2018
Advanced nanomedicine approaches applied for treatment of skin carcinoma
Harsimran Kaur1, Prashant Kesharwani2
1Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
Abstract:
Skin-cancer is the commonest malignancy affecting huge proportion of the population, reaching heights in terms of morbidity. The treatment strategies are presently focusing on surgery, radiation and chemotherapy, which eventually cause destruction to unaffected cells. To overcome this limitation, wide range of nanoscaled materials have been recognized as potential carriers for delivering selective response to cancerous cells and neoplasms. Nanotechnological approach has been tremendously exploited in several areas, owing to their functional nanometric dimensions. The alarming incidence of skin cancer engenders burdensome effects worldwide, which is further awakening innovational medicinal approaches, accompanying target specific drug delivery tools for coveted benefits to provide reduced toxicity and tackle proliferative episodes of skin cancer. The developed nanosystems for anti-cancer agents include liposomes, ethosomes, nanofibers, solid lipid nanoparticles and metallic nanoparticles, which exhibit pronounced outcomes for skin carcinoma. In this review, skin cancer with its sub-types is explained in nutshell, followed by compendium of specific nanotechnological tools presented, in addition to therapeutic applications of drug-loaded nano systems for skin cancer.
Insights
Nanotechnology offers targeted drug delivery for skin cancer, overcoming limitations of traditional treatments like surgery and chemotherapy. This approach utilizes nanosystems to reduce toxicity and effectively combat cancer cell proliferation.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Skin cancer is a prevalent malignancy with significant morbidity.
- Current treatments (surgery, radiation, chemotherapy) lack specificity and harm healthy cells.
- There is a need for innovative approaches to target skin cancer effectively.
Purpose of the Study:
- To review the application of nanotechnology in skin cancer treatment.
- To present various nanocarrier systems for targeted drug delivery.
- To discuss the therapeutic potential of drug-loaded nanosystems for skin carcinoma.
Main Methods:
- Review of existing literature on skin cancer and nanomedicine.
- Compilation of different nanotechnological tools used for cancer therapy.
- Analysis of therapeutic applications and outcomes of nanosystems in skin cancer.
Main Results:
- Nanoscaled materials show promise as selective carriers for anti-cancer agents.
- Various nanosystems (liposomes, ethosomes, nanoparticles) are effective in treating skin cancer.
- Nanotechnology enables targeted drug delivery, reducing toxicity and improving efficacy.
Conclusions:
- Nanotechnology provides a promising strategy for targeted skin cancer treatment.
- Nanosystems offer reduced toxicity and improved outcomes compared to conventional therapies.
- Further research into nanomedicine is crucial for advancing skin cancer care.
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