A γδ T-cell Imprint in a Rare Skin Tumor

In-depth immune profiling can guide the development and targeting of cancer immunotherapies. In this issue, Gherardin and colleagues find a strong signature of γδ T cells in the immune infiltrate of Merkel cell carcinoma that correlates with a more favorable prognosis and heightened responsiveness to checkpoint inhibitors. This may lead to future γδ T cell-targeted immunotherapies.See article by Gherardin et al., p. 612.