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Published on: November 20, 2015
[SEVERE INFECTIOUS DISEASE AS A PREDICTOR OF CRITICAL ILLNESS ENCEPHALOPATHY IN CHILDREN (CLINICAL CASE)]
N Skripchenko1, E Egorova2, A Vilnits1
11Pediatric Research and Clinical Center for Infectious Diseases, Saint-Petersburg;2Saint-Petersburg State Pediatric Medical University, Russia.
Insights
Mechanical ventilation for children with severe infections can cause critical encephalopathy. Early Cytoflavin treatment may mitigate neurological deficits in these vulnerable patients.
Area of Science:
- Pediatrics
- Neurology
- Critical Care Medicine
Background:
- Infectious diseases in children often lead to critical conditions requiring mechanical ventilation.
- Mechanical ventilation, while life-saving, poses risks including acute encephalopathy, pneumonia, and neuromuscular complications.
Observation:
- Critical encephalopathy affects 75% of children with severe infections on mechanical ventilation.
- Long-term neurological deficits are observed in 33% of survivors after one year.
Findings:
- Timely diagnosis and prediction of encephalopathy are crucial for pediatric patients.
- Cytoflavin, a complex drug with antioxidant, antiplatelet, anti-inflammatory, and remyelinating properties, shows promise in treatment.
Implications:
- Early and adequate therapy with Cytoflavin may improve outcomes for children experiencing critical encephalopathy.
- This case highlights the potential of Cytoflavin in managing neurological complications associated with critical illness and mechanical ventilation in children.
Abstract:
In childhood, infectious diseases, as a rule, are generalized in nature with the development of urgent or critical conditions that require the transfer of the child to mechanical ventilation. A child's stay on mechanical ventilation, on the one hand, is vital, on the other hand, it is a factor that threatens the development of acute encephalopathy, mechanical ventilation associated pneumonia, polyneuropathy and myopathy of critical conditions. According to the authors, the incidence of critical encephalopathy in patients with generalized infectious diseases who are on mechanical ventilation is 75%, and in the long-term (after 1 year) outcome in convalescents, the frequency of neurological deficit reaches 33%. In this regard, it is extremely important to timely diagnose and predict encephalopathy, including in children, as well as early adequate therapy with the inclusion of a complex action drug Cytoflavin, which has not only an antioxidant, antiplatelet effect, but also anti-inflammatory and remyelinating. The article presents a clinical case of critical state encephalopathy, which developed against the background of a severe infectious disease after artificial ventilation with effective timely use of Cytoflavin.
