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The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium

Weikang Ma1, Marcus Henze2, Robert L Anderson2

  • 1BioCAT, Department of Biological Sciences, Illinois Institute of Technology, Chicago (W.M., H.G., T.I.).

Circulation Research
|August 9, 2021
PubMed

Keywords:
myocardial contractionmyofibrilssarcomeresswine

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The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open.