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Updated: Oct 25, 2025

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease

Published on: November 28, 2012

Aortic allograft infection risk.

James C Witten¹, Penny L Houghtaling², Nabin K Shrestha³

¹Department of Thoracic and Cardiovascular Surgery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

The Journal of Thoracic and Cardiovascular Surgery

|August 9, 2021

Summary

This summary is machine-generated.

Cryopreserved allograft aortic root replacements show low infection rates, even in patients with infective endocarditis. These findings support the continued use of allografts for aortic root replacement, especially in complex cases.

Keywords:

endocarditis prosthetic valve root abscess

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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

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Area of Science:

Cardiovascular Surgery
Infectious Diseases
Transplantation Immunology

Background:

The intrinsic risk of infection associated with cryopreserved allograft aortic root replacements is not well understood.
Allografts have a long history of use in aortic valve replacement, but data on infection rates are limited.

Purpose of the Study:

To determine the intrinsic risk of allograft infection in aortic root replacements.
To identify risk factors for allograft infection in patients undergoing nonendocarditis and infective endocarditis procedures.

Main Methods:

A retrospective analysis of 2110 allograft aortic valve recipients from 1987 to 2017.
Risk factor identification using hazard function decomposition and machine learning.
Long-term follow-up to assess allograft infection rates.

Main Results:

At 20 years, the probability of allograft infection was 5.6% for nonendocarditis and 14% for endocarditis indications.
Risk factors for nonendocarditis included younger patient age and older donor age.
Risk factors for endocarditis included earlier implant year, injection drug use, and younger age.

Conclusions:

Low infection rates support the continued use of allografts in aortic root replacement.
Allografts are particularly valuable for treating invasive endocarditis of the aortic root.
The study provides evidence for the safety and efficacy of allografts in diverse patient populations.